Dr. Court has just published a paper identifying what he believes is the main mutation (CYP2B11-H3) that causes slow drug metabolism in Greyhounds, and he has found that Deerhounds have the same mutation. Although he still has some work to do to confirm this, this is very exciting news for us.
Some more information on diet-related DCM.
This article is the latest information in exciting research that looks like it is finally cracking the mystery of gastric dilatation-volvulus (gastric torsion/bloat), at least in Great Danes.
The SDCA Health & Genetics Committee has published two position statements on genetic testing, the first being an introduction to genetic testing and the second on Factor VII. It appears that we will have more genetic tests sooner rather than later (YAY!), so it is imperative that all breeders understand how to use these tests and owners understand how they are used so we can all work together to eliminate these disease-causing variants without reducing the breed’s gene pool.
As our gene pool continues to shrink (only 14 litters and 104 dogs were registered with the AKC in 2016!), it is imperative we keep as many dogs in the breeding population as possible. One way to do this is to use the frozen semen many breeders around the world have collected and stored.Read more
If someone you know who has had a dog that bled or a first-degree relative of a dog that bled, and fibrinolysis was suspected (as opposed to Factor VII), please send them this blog post so they can be included. We are really having a hard time finding samples from affected dogs, so we need everyone to spread the word!
An article co-written by SDCA Health and Genetics Chair John Dillberger, DVM PhD, has just been published in Canine Genetics and Epidemiology. Entitled “Osteosarcoma Inheritance in Two Families of Scottish Deerhounds,” you can read the entire article here, or here is the plain English summary:
Trimethoprim-sulfa antibiotics are widely used because they’re inexpensive, effective against all kinds of bacteria, and considered very safe. Unfortunately, they aren’t without side-effects. Deerhounds have more than their share of serious consequences from these drugs.
The Health & Genetics Committee is very excited to announce a new osteosarcoma project!
This project undertakes the very important task of seeing whether Deerhounds have any of the mutations found to date in two close relatives, the Greyhound and Irish Wolfhound, as well as Rottweilers, and lays the groundwork for future studies.